The expression of genes encoding antioxidative and Phase II detoxification enzymes is
induced in cells exposed to electrophilic compounds and phenolic antioxidants. Induction of …

The induction of many antioxidant and phase II drug-metabolizing enzymes by phenolic
antioxidants and electrophilic compounds is regulated at the transcriptional level. The …

The antioxidant response element (ARE) mediates the transcriptional activation of many
genes encoding phase II drug-metabolizing enzymes in response to oxidative stress. Recent …

An antioxidant responsive element (ARE) or electrophile responsive element (EpRE)
mediates the transcriptional activation of genes encoding phase II drug metabolizing …

Publisher Summary This chapter outlines the role of Nrf2 in the activation of antioxidation
enzyme via antioxidant responsive element/electrophile responsive element (ARE/EpRE) …

ABSTRACT NF‐E2‐related factor 2 (Nrf2) is a basic leucine zipper transcription factor that
binds to the promoter sequence “antioxidant responsive element (ARE)” leading to …

Nf-E2 related factor-2 (Nrf2) is a basic leucine zipper transcription factor that binds and
activates the antioxidant response element (ARE) in the promoters of many antioxidant and …

A central mechanism in cellular defence against oxidative or electrophilic stress is mediated
by transcriptional induction of genes via the ARE (antioxidant-response element), a cis …

A coordinated cellular response to oxidative stress occurs in part through transcriptional
regulation via a cis-acting sequence known as the antioxidant response element (ARE). NF …

Publisher Summary Antioxidants are substances that delay or prevent the oxidation of
cellular oxidizable substrates. The various antioxidants exert their effect by scavenging …