A dominant negative mutant of microphthalmia transcription factor (MITF) lacking two transactivation domains suppresses transcription mediated by wild type MITF and …

J Vachtenheim, B Drdová - Pigment cell research, 2004 - Wiley Online Library
Microphthalmia transcription factor (MITF) positively regulates transcription of differentiation‐
related genes in several cell lineages, including melanocytes. Recent data also indicate a …

Microphthalmia‐associated transcription factor (MITF) is required but is not sufficient to induce the expression of melanogenic genes

C Gaggioli, R Buscà, P Abbe, JP Ortonne… - Pigment cell …, 2003 - Wiley Online Library
Microphthalmia‐associated transcription factor (MITF) plays a pivotal role in melanocyte
survival and differentiation. Nevertheless, until now it has not been possible to show that …

Role of microphthalmia transcription factor (Mitf) in melanoma differentiation

F Lekmine, CK Chang, N Sethakorn, TKD Gupta… - Biochemical and …, 2007 - Elsevier
We transfected the melanocyte-specific Mitf-M isoform into the aggressive melanoma UISO-
Mel-6 cell lines. Our data show that Mitf decreases cell proliferation and results in cells …

Inhibition of MITF transcriptional activity independent of targeting p300/CBP coactivators

J Vachtenheim, B Šestáková… - Pigment cell …, 2007 - Wiley Online Library
Microphthalmia‐associated transcription factor (MITF) activates the expression of
melanocyte‐specific markers and promotes the survival of embryonic, adult and malignant …

[HTML][HTML] MITF-M, a “melanocyte-specific” isoform, is expressed in the adult retinal pigment epithelium

J Maruotti, T Thein, DJ Zack, N Esumi - Pigment cell & melanoma …, 2012 - ncbi.nlm.nih.gov
The gene residing at the microphthalmia locus that causes white and small eye phenotype
in mice when mutated was cloned and named microphthalmia-associated transcription …

Subcellular localization and stability of MITF are modulated by the bHLH‐Zip domain

V Fock, SR Gudmundsson… - Pigment cell & …, 2019 - Wiley Online Library
Microphthalmia‐associated transcription factor (MITF) is a member of the basic helix–loop–
helix leucine zipper (bHLH‐Zip) family and functions as the master regulator of the …

MITF: master regulator of melanocyte development and melanoma oncogene

C Levy, M Khaled, DE Fisher - Trends in molecular medicine, 2006 - cell.com
Microphthalmia-associated transcription factor (MITF) acts as a master regulator of
melanocyte development, function and survival by modulating various differentiation and …

Regulation of pigment cell‐specific gene expression by MITF

S Shibahara, KENI YASUMOTO, S Amae… - Pigment Cell …, 2000 - Wiley Online Library
Melanocyte and retinal pigment epithelium (RPE) specifically express tyrosinase and other
melanin‐producing enzymes. Microphthalmia‐associated transcription factor (Mitf), encoded …

MITF: A Matter of Life and Death for Developing Melanocytes

H Arnheiter, L Hou, MTT Nguyen, K Bismuth… - From Melanocytes to …, 2006 - Springer
Since its discovery over a decade ago, the microphthalmia-associated transcription factor
(MITF), has moved ever more to the center of pigment cell biology. Not only has MITF been …

MITF—the first 25 years

CR Goding, H Arnheiter - Genes & development, 2019 - genesdev.cshlp.org
All transcription factors are equal, but some are more equal than others. In the 25 yr since
the gene encoding the microphthalmia-associated transcription factor (MITF) was first …