Background: Poorly differentiated and anaplastic thyroid carcinomas have a rather poor
prognosis. The development of relevant model systems to unravel in vitro and in vivo the …

Objective To investigate the molecular underpinnings of thyroid cancer, preclinical cell line
models are crucial; however,∼ 40% of these have been proven to be either duplicates of …

Background: Tumor-derived cell lines are widely used to study the mechanisms involved in
thyroid carcinogenesis but recent studies have reported redundancy among thyroid cancer …

Thyroid cancer is the most common endocrine malignancy and the incidence is rising.
Currently, there are no effective treatments for patients with advanced forms of thyroid …

The overall prognosis of thyroid cancer is excellent, but some patients have grossly invasive
disease and distant metastases with limited responses to systemic therapies. Thus, relevant …

Cell lines are crucial to elucidate mechanisms of tumorigenesis and serve as tools for
cancer treatment screenings. Therefore, careful validation of whether these models have …

An animal model of undifferentiated thyroid carcinoma (UTC), which may be useful for
studying tumorigenesis and response to new therapies, is described. The UTC human cell …

Simple Summary Advancements in thyroid cancer are dependent on the availability of
experimental models allowing for investigation in the laboratory setting. Here, we detail the …

A significant number of well-differentiated thyroid cancers progress or recur, becoming
resistant to current therapeutic options. Mouse models recapitulating the genetic and …

Background: Thyroid cancer is the most common endocrine malignancy worldwide. Primary
treatment with surgery and radioactive iodine is usually successful, however, there remains …