Golbert L, Kolling JHG, Leitao AH, Martins L, et al. H-RAS gene expression in human
multinodular goiter. Histol Histopathol 2007; 22: 409–416. Grassadonia A, Tinari N …

The RAS protooncogene has an important, although not yet established role in thyroid
neoplasia. In this study, we evaluated the H-RAS mRNA and protein levels in human …

A transformação neoplásica resulta de uma série de alterações genéticas, envolvendo
ativação de proto-oncogenes e inativação de genes supressores tumorais. Ativação do …

ENDOCRINOLOGY AND METABOLISM Page 1 8 ENDOCRINOLOGY AND METABOLISM
Thyrotoxicosis COMMON CAUSES - Graves' disease (hyperplasia) - toxic nodular goitre …

Many genetic and environmental factors contribute to the development of multinodular goiter
(MNG). Xb130 is an adaptor protein for signal transduction that is highly expressed in thyroid …

Castro P, Xia C, Gomez L, et al. Interleukin-8 expression is increased in senescent prostatic
epithelial cells and promotes the development of benign prostatic hyperplasia. Prostate …

Introduction: Standard pre-operative diagnosis of nodular goitre is not always conclusive.
The decision about nodular goitre surgery is increasingly based on molecular methods. The …

The small G proteins of the RAS superfamily act as molecular switches in the transduction of
cellular signals critical for a wide range of normal developmental events as well as …

36. The authors thank E. Turk for contributions to the early stages of the project; J.
Whitelegge for assistance with the electrospray mass spectroscopy; and R. Kaback, K …

Mutations of ras are tumor-initiating events for many cell types, including thyrocytes. To
explore early consequences after oncogenic Ras activation, we developed a doxycycline …