The new millennium brought the transition from classical therapy to targeted cancer therapy.
Although multiple pathways are involved in cancer initiation and progression, the RAS …

Background: The familial clustering of multinodular goitres (MNGs) with a dominant mode of
inheritance has been repeatedly reported. Linkage studies have revealed several genetic …

The renin–angiotensin–aldosterone system (RAAS) regulates blood pressure homeostasis
and vascular injury and repair responses. The RAAS was originally thought to be an …

Prostate cancer (PCa) is a leading cause of cancer death among men, with greater
prevalence of the disease among the African American population in the US. Activator of G …

Ras is a membrane-bound small guanosine triphosphatase (GTPase) that mediates signals
from receptor tyrosine kinases to members of the mitogen-activated protein kinase (MAPK) …

Thyroid cancer's incidence has increased dramatically over the last years and it now
accounts for 2.6% of all new cancers when epithelial skin cancers are excluded. This …

This article has been published under the terms of the Creative Commons Attribution
License (CC-BY; https://creativecommons. org/licenses/by/4.0/), which permits unrestricted …

Methods: DNA was extracted from 72 fresh frozen thyroid samples and 26 paraffin-
embedded formalin-fixed samples. The cohort contained 83 PTCs (56 FVPTCs, 14 mixed …

Given the high frequency of ras oncogene activation in several common human cancers, its
signal pathways are an important target for novel therapy. For practical reasons, however …