It is increasingly evident that neuroinflammatory mechanisms are implicated in the
pathogenesis of the central nervous system (CNS) complications (intracranial hypertension …

A robust neuroinflammatory response characterized by microglial activation and increased
brain production of pro-inflammatory cytokines is common in acute liver failure (ALF) …

The presence and severity of a systemic inflammatory response is a major predictor of brain
edema and encephalopathy in acute liver failure (ALF) and polymorphisms of the gene …

Neuropathologic investigations in acute liver failure (ALF) reveal significant alterations to
neuroglia consisting of swelling of astrocytes leading to cytotoxic brain edema and …

Continued elucidation of the mechanisms of brain edema in acute liver failure (ALF) has
established ammonia and the astrocyte as major players in its pathogenesis. The …

Encephalopathy and brain edema are serious central nervous system complications of liver
failure. Recent studies using molecular probes and antibodies to cell-specific marker …

Brain edema and associated increase in intracranial pressure continue to be lethal
complications of acute liver failure (ALF). Abundant evidence suggests that the edema in …

The neurological involvement in acute liver failure (ALF) is characterized by arousal
impairment with progression to coma. There is a growing body of evidence that …

The encephalopathy that is associated with acute liver failure (ALF)[1] is characterized by
the occurrence of cerebral oedema which results in elevation in intracranial pressure (ICP) …

Systemic inflammation is common in liver failure and its acquisition is a predictor of hepatic
encephalopathy severity. New studies provide convincing evidence for a role of …