Chemokines play an important role in immune and inflammatory responses by inducing
migration and adhesion of leukocytes, and have also been reported to modulate osteoclast …

Human osteoclast formation from monocyte precursors under the action of receptor activator
of nuclear factor-κB ligand (RANKL) was suppressed by granulocyte macrophage colony …

Although much has been learned recently of the mechanisms by which the differentiation of
osteoclasts is induced, less is known of the factors that regulate their migration and …

OBJECTIVES: We compared osteoclast (OC) formation in bone marrow–derived
macrophages (BMM) from C57BL/6 (B/6) and BALB/c (B/c) mice. After stimulation of receptor …

Human osteoclasts were differentiated using receptor activator of NFκB ligand (RANKL) and
macrophage colony stimulating factor (M‐CSF) from colony forming unit‐granulocyte …

Abstract Chemokine CCL4 (MIP-1β) is released from osteoblast cells to restore the
homeostasis of hematopoietic stem cells during the activation of bone marrow. In this study …

Macrophage inflammatory protein-1α (MIP-1α) is a member of the CC chemokines. We have
previously reported the use of a whole bone marrow culture system to show that MIP-1α …

CXCL2 has been known to regulate immune functions mainly by chemo-attracting
neutrophils. In this study, we show that CXCL2 can be induced by receptor activator of NF …

Chemoattractants that recruit OC precursors to locally inflamed sites of resorption are not
well known. A chemokine receptor, CCR1, was expressed in OC precursors and elevated in …

Osteoclasts, the multinucleated cells that resorb bone, differentiate from hemopoietic
precursors of the monocyte/macrophage lineage in the presence of M-CSF and receptor …