Abstract Background/Aims: Dysregulation of integrins is a feature of tissue remodeling in
autosomal-dominant polycystic kidney disease (ADPKD). The alpha 8 beta 1 integrin (α8β1) …

Autosomal dominant polycystic kidney disease (ADPKD), a common genetic disease, is
characterized by the development of hypertension and end stage renal disease. An increase …

Extracellular matrix alterations have been suggested to be part of the early events occurring
in Autosomal Dominant Polycystic Kidney Disease (ADPKD), a disease characterized by …

BACKGROUND: Two genetic loci, PKD I and PKD2, have been identified as being
responsible for ADPKD, and PKD1 is known to be associated with a poor prognosis …

Background/Aim: A significant phenotypical variability is observed in autosomal dominant
polycystic kidney disease (ADPKD). The variability cannot be fully explained by the genetic …

Glomerular filtration rate decline (GFRd) is variable in autosomic dominant polycystic kidney
disease (ADPKD). In 88 ADPKD patients, GFRd was assessed by 1/S (Cr) and compared …

Background: A significant phenotypical variability is observed in autosomal dominant
polycystic kidney disease (ADPKD). The variability can not be fully explained by the genetic …

ADPKD is the most common hereditary renal disease. IGAN is a mesangial proliferative
glomerulonephritis characterized by diffuse mesangial deposition of immunoglobulin A. ET …

Abstract Dysregulation of polycystin-1 (PC1) leads to autosomal dominant polycystic kidney
disease (ADPKD), a disorder characterized by the formation of multiple bilateral renal cysts …

Background. Autosomal dominant polycystic kidney disease (ADPKD) shows a variable
clinical course that is not fully explained by the genetic heterogeneity of this disease. We …