Microphthalmia‐associated transcription factor in melanoma development and MAP‐kinase pathway targeted therapy

C Wellbrock, I Arozarena - Pigment cell & melanoma research, 2015 - Wiley Online Library
Malignant melanoma is a neoplasm of melanocytes, and the microphthalmia‐associated
transcription factor (MITF) is essential for the existence of melanocytes. MITF's relevance for …

MITF in melanoma: mechanisms behind its expression and activity

ML Hartman, M Czyz - Cellular and Molecular Life Sciences, 2015 - Springer
MITF (microphthalmia-associated transcription factor) represents a melanocytic lineage-
specific transcription factor whose role is profoundly extended in malignant melanoma. Over …

MITF: master regulator of melanocyte development and melanoma oncogene

C Levy, M Khaled, DE Fisher - Trends in molecular medicine, 2006 - cell.com
Microphthalmia-associated transcription factor (MITF) acts as a master regulator of
melanocyte development, function and survival by modulating various differentiation and …

Molecular network associated with MITF in skin melanoma development and progression

I Yajima, MY Kumasaka, ND Thang, Y Goto… - Journal of skin …, 2011 - Wiley Online Library
Various environmental and genetic factors affect the development and progression of skin
cancers including melanoma. Melanoma development is initially triggered by environmental …

MITF in normal melanocytes, cutaneous and uveal melanoma: a delicate balance

MC Gelmi, LE Houtzagers, T Strub, I Krossa… - International journal of …, 2022 - mdpi.com
Microphthalmia-associated transcription factor (MITF) is an important regulator of
melanogenesis and melanocyte development. Although it has been studied extensively in …

[HTML][HTML] Pro-survival role of MITF in melanoma

ML Hartman, M Czyz - Journal of Investigative Dermatology, 2015 - Elsevier
Melanoma is a therapy-resistant skin cancer due to numerous mechanisms supporting cell
survival. Although components of melanoma cytoprotective mechanisms are overexpressed …

[HTML][HTML] A conditional zebrafish MITF mutation reveals MITF levels are critical for melanoma promotion vs. regression in vivo

JA Lister, A Capper, Z Zeng, ME Mathers… - Journal of Investigative …, 2014 - Elsevier
The microphthalmia-associated transcription factor (MITF) is the “master melanocyte
transcription factor” with a complex role in melanoma. MITF protein levels vary between and …

Novel MITF targets identified using a two‐step DNA microarray strategy

KS Hoek, NC Schlegel, OM Eichhoff… - Pigment cell & …, 2008 - Wiley Online Library
Malignant melanoma is a chemotherapy‐resistant cancer with high mortality. Recent
advances in our understanding of the disease at the molecular level have indicated that it …

Microphthalmia-associated transcription factor gene amplification in metastatic melanoma is a prognostic marker for patient survival, but not a predictive marker for …

S Ugurel, R Houben, D Schrama, H Voigt… - Clinical cancer …, 2007 - AACR
Purpose: The microphthalmia-associated transcription factor (MITF) is regarded as a key
oncogene of the melanocytic lineage since it was detected by a genome-wide analysis to be …

Oncogenic BRAF regulates melanoma proliferation through the lineage specific factor MITF

C Wellbrock, S Rana, H Paterson, H Pickersgill… - PloS one, 2008 - journals.plos.org
The Microphthalmia-associated transcription factor (MITF) is an important regulator of cell-
type specific functions in melanocytic cells. MITF is essential for the survival of pigmented …