The maturation state of dendritic cells (DCs) is an important determinant for the initiation and
regulation of adaptive immune responses. In this study, we wanted to assess whether …

In this report, we have studied the immunogenicity of the nominal antigen, carcinoembryonic
antigen (CEA), and that of an anti-idiotype antibody, 3H1, which mimics CEA and can be …

Pulsing dendritic cells (DCs) with tumor cell-derived mRNA is regarded as an attractive
alternative in the development of DC-based tumor vaccines. Our aim is to improve the …

We developed a colorectal cancer vaccine, comprised of a human CEA gene-containing
plasmid packaged inside the bovine papillomavirus like particles (VLP-CEA vaccine). Oral …

Carcinoembryonic antigen (CEA) is a well-known tumor antigen. It is found in serum of
various cancers including colorectal carcinoma, gastric carcinoma. Uncontrolled level of …

The goal of cancer therapy remains as the long‐term eradication of tumor cells without
adverse effects on normal tissue. Conventional approaches utilizing chemotherapy and …

In situations where well-established approaches such as surgery, radiation therapy and
chemotherapy fail to help cancer patients, immunotherapy has the potential to be an …

Abstract Background: Dendritic Cells (DC) are potent antigen presenting cells with the ability
to prime naïve T cells and convert them to cytotoxic T-lymphocytes (CTL). We evaluated the …

Background: Dendritic cells (DCs) are the professional antigen-presenting cells of the
immune system. We have demonstrated that vaccination of autologous ex vivo cultured DCs …

Many antigens associated with human tumors are overexpressed in tumor cells as
compared with normal tissues; these “self” tumor-associated antigens are also expressed …