Glucocorticoids mediate muscle atrophy in many catabolic states. Myostatin expression, a
negative regulator of muscle growth, is increased by glucocorticoids and myostatin …

The mechanisms by which excessive glucocorticoids cause muscular atrophy remain
unclear. We previously demonstrated that dexamethasone increases the expression of …

Excess glucocorticoids (GCs) cause muscle atrophy. Glucocorticoid-induced muscle atrophy
is associated with increased intramuscular myostatin expression. Myostatin is a negative …

Some recent studies showed that the glucocorticoid-induced muscle atrophy was associated
with myostatin, a negative regulator of skeletal muscle. In this study, two experiments were …

We cloned and characterized a 3.3-kb fragment containing the 5′-regulatory region of the
human myostatin gene. The promoter sequence contains putative muscle growth response …

Myostatin is a master regulator of myogenesis and early postnatal skeletal muscle growth.
However, myostatin has been also involved in several forms of muscle wasting in adulthood …

Mutations in the myostatin gene are associated with hypermuscularity, suggesting that
myostatin inhibits skeletal muscle growth. We postulated that increased tissue-specific …

Myostatin inhibits skeletal muscle development. Therefore, we sought to determine whether
larger body and muscle mass in male mice was associated with lower mRNA and protein …

Constitutive myostatin gene knockout in mice causes excessive muscle growth during
development. To examine the effect of knocking out the myostatin gene after muscle has …

Myostatin is hypothesized to regulate skeletal muscle mass and to be a potential target for
therapeutic intervention in sarcopenia. To clarify whether myostatin is invariably associated …