Myostatin inhibits myogenesis. Therefore, we sought to determine if mice lacking the
myostatin gene [Mstn (-/-)] would lose less muscle mass than wild-type mice during 7 days of …

A human therapeutic that specifically modulates skeletal muscle growth would potentially
provide a benefit for a variety of conditions including sarcopenia, cachexia, and muscular …

Myostatin is a secreted protein that negatively regulates skeletal muscle mass determining
both muscle fiber number and size. The myostatin pathway is conserved and regulates …

Obesity and insulin resistance cause serious consequences to human health. To study
effects of skeletal muscle growth on obesity prevention, we focused on a key gene of …

Purpose There is mounting evidence that skeletal muscle produces and secretes
biologically active proteins or “myokines” that facilitate metabolic cross talk between organ …

Myostatin is an important negative regulator of skeletal muscle growth, while androgens are
strong positive effectors. In order to investigate the possible interaction between myostatin …

Previous findings have provided strong evidence that myostatin functions as a negative
regulator of muscle mass during development and growth. In the present study, we test the …

Myostatin mutations in mice and cattle are associated with increased muscularity,
suggesting that myostatin is a negative regulator of skeletal muscle mass. To test the …

There is much interest in developing anti-myostatin agents to reverse or prevent muscle
atrophy in adults, so it is important to characterize the effects of reducing myostatin activity …

Inhibitors of myostatin, a negative regulator of skeletal muscle mass, are being developed to
mitigate aging‐related muscle loss. Knock‐out (KO) mouse studies suggest myostatin also …