An empirical study of the effect of the control rate as a predictor of treatment efficacy in meta‐analysis of clinical trials
If the control rate (CR) in a clinical trial represents the incidence or the baseline severity of
illness in the study population, the size of treatment effects may tend to vary with the size of …
illness in the study population, the size of treatment effects may tend to vary with the size of …
Random-effects model for meta-analysis of clinical trials: an update
R DerSimonian, R Kacker - Contemporary clinical trials, 2007 - Elsevier
The random-effects model is often used for meta-analysis of clinical studies. The method
explicitly accounts for the heterogeneity of studies through a statistical parameter …
explicitly accounts for the heterogeneity of studies through a statistical parameter …
On the equivalence of meta‐analysis using literature and using individual patient data
T Mathew, K Nordstrom - Biometrics, 1999 - Wiley Online Library
When data come from several independent studies for the purpose of estimating treatment‐
control differences, meta‐analysis can be carried out either on the best linear unbiased …
control differences, meta‐analysis can be carried out either on the best linear unbiased …
Variation in baseline risk as an explanation of heterogeneity in meta‐analysis
SD Walter - Statistics in Medicine, 1997 - Wiley Online Library
A relationship of baseline risk to treatment effect size has been suggested as a possible
explanation of between‐study heterogeneity in meta‐analyses. To address this question, we …
explanation of between‐study heterogeneity in meta‐analyses. To address this question, we …
The implications of publication bias for meta‐analysis' other parameter
D Jackson - Statistics in medicine, 2006 - Wiley Online Library
Perhaps the greatest threat to the validity of a meta‐analysis is the possibility of publication
bias, where studies that are interesting or statistically significant are more likely to be …
bias, where studies that are interesting or statistically significant are more likely to be …
A refined method for multivariate meta‐analysis and meta‐regression
Making inferences about the average treatment effect using the random effects model for
meta‐analysis is problematic in the common situation where there is a small number of …
meta‐analysis is problematic in the common situation where there is a small number of …
On tests of the overall treatment effect in meta‐analysis with normally distributed responses
J Hartung, G Knapp - Statistics in medicine, 2001 - Wiley Online Library
For the meta‐analysis of controlled clinical trials or epidemiological studies, in which the
responses are at least approximately normally distributed, a refined test for the hypothesis of …
responses are at least approximately normally distributed, a refined test for the hypothesis of …
Clinically useful measures of effect in binary analyses of randomized trials
JC Sinclair, MB Bracken - Journal of clinical epidemiology, 1994 - Elsevier
The results of a randomized clinical trial can be reported using relative and/or absolute
estimators of treatment effect. These various measures convey different information, and the …
estimators of treatment effect. These various measures convey different information, and the …
Statistical methods for assessing the influence of study characteristics on treatment effects in 'meta‐epidemiological'research
Biases in systematic reviews and meta‐analyses may be examined in 'meta‐
epidemiological'studies, in which the influence of trial characteristics such as measures of …
epidemiological'studies, in which the influence of trial characteristics such as measures of …
Multivariable modelling for meta‐epidemiological assessment of the association between trial quality and treatment effects estimated in randomized clinical trials
V Siersma, B Als‐Nielsen, W Chen, J Hilden… - Statistics in …, 2007 - Wiley Online Library
Methodological deficiencies are known to affect the results of randomized trials. There are
several components of trial quality, which, when inadequately attended to, may bias the …
several components of trial quality, which, when inadequately attended to, may bias the …
相关搜索
- meta analysis control rate
- predictor of treatment efficacy
- meta analysis treatment effect
- meta analysis baseline risk
- meta analysis explanation of heterogeneity
- meta analysis publication bias
- trial quality treatment effects
- measures of treatment effects
- overall treatment effect
- multivariable modelling treatment effects
- treatment efficacy control rate
- meta analysis treatment efficacy
- meta analysis random effects