Background Detecting organ and tissue damage is essential for early diagnosis, treatment
decisions, and monitoring disease progression. Methylation-based assays offer a promising …

DNA methylation is an epigenetic mechanism that contributes to cell regulation and
development, and different methylation patterns allow for the identification of cell and tissue …

The diagnosis of many brain disorders is challenging due to the nonspecific clinical
presentation and/or the lack of accurate biomarkers. In addition, many neurological …

DNA methylation is the dominant epigenetic mechanism for regulating gene expression in
mammals, playing crucial roles in development, differentiation, and tissue homeostasis …

Minimally invasive detection of cell death could prove an invaluable resource in many
physiologic and pathologic situations. Cell-free circulating DNA (cfDNA) released from dying …

Aim: Liquid biopsies analyzing cell-free DNA (cfDNA) methylation in plasma offer a
noninvasive diagnostic for diseases, with the potential of aging biomarkers underexplored …

DNA methylation is an important epigenetic marker that affects gene expression. Cell-free
DNA methylation detection is a promising approach as abnormal distribution of DNA …

Small amounts of tumor-derived DNA molecules can be found as circulating cell-free (ccf)
DNA molecules that can be isolated from the serum/plasma of patients. The analysis of cell …

As a noninvasive blood testing, the detection of cell‐free DNA (cfDNA) methylation in
plasma has raised an increasing interest due to diagnostic applications. Although …

Detection of cellular changes in tissue biopsies has been the basis for cancer diagnostics.
However, tissue biopsies are invasive and limited by inaccuracies due to sampling …