Liver damage is typically inferred from serum measurements of cytoplasmic liver enzymes.
DNA molecules released from dying hepatocytes are an alternative biomarker, unexplored …

DNA methylation is of paramount importance for the evolution of human cancers. Its high
sensitivity and specificity make it a potential biomarker for early cancer screening in the …

Radiation therapy is an effective cancer treatment, although damage to healthy tissues is
common. Here we analyzed cell-free, methylated DNA released from dying cells into the …

Abstract Analysis of the methylome of tumor cell-free deoxyribonucleic acid (DNA; cfDNA)
has emerged as a powerful non-invasive technique for cancer subtyping and prognosis …

Alteration of DNA methylation patterns at the 5′ position of cytosines, in the context of CpG
dinucleotides, is one of the most promising epigenetic biomarkers for many biomedical …

DNA methylation patterns are altered in numerous diseases and often correlate with
clinically relevant information such as disease subtypes, prognosis and drug response. With …

Background: Alterations in DNA methylation play a key role in tumor initiation, and
methylation markers are well established for detecting various cancer types. Cancer-specific …

Disease-specific alterations of the cell-free DNA methylation status are frequently found in
serum samples and are currently considered to be suitable biomarkers. Candidate markers …

Cell-free DNA (cfDNA) analysis has become essential in cancer diagnostics and prenatal
testing. We present cfNOMe, a two-in-one method of measuring cfDNA cytosine methylation …

Identification of patients at risk for post-transplant complications is a major challenge, but it
will improve clinical care and patient health after organ transplantation. The poor predictive …