Abstract Angiotensin-(1–7) is a bioactive component of the renin–angiotensin system that is
formed endogenously and induces nitric oxide release in several tissues. The l …

Despite the classical peripheral pronociceptive effect of noradrenaline (NA), recently studies
showed the involvement of NA in antinociceptive effect under immune system interaction. In …

Angiotensins (Angs) modulate blood pressure, hydro-electrolyte composition, and
antinociception. Although Ang (5–8) has generally been considered to be inactive, we show …

Abstract Angiotensin-(1–7)[Ang-(1–7)] develops its functions interacting with Mas receptor.
Mas receptor was recently identified in the DRG and its activation by Ang-(1–7) resulted in …

Substances derived from plants play an important role in the development of new analgesic
drugs, among them, triterpenoids. The connection between the participation of L …

BACKGROUND: The involvement of the l-arginine/nitric oxide (NO)/cyclic guanosine
monophosphate (cGMP) pathway in antinociception has been implicated as a molecular …

The l-arginine/nitric oxide/cyclic GMP pathway has been proposed as the mechanism of
action for peripheral antinociception concerning several groups of drugs, including opioids …

The involvement of nitric oxide (NO), cyclic GMP and ATP-sensitive K+ channels in the
antinociceptive effect of ketorolac was assessed using the formalin test in the rat. Local …

The involvement of the nitric oxide (NO)/cyclic GMP pathway in the molecular mechanisms
of antinociceptive drugs like morphine has been previously shown by our group …

Abstract N‐palmitoyl‐ethanolamine (PEA) is an endogenous substance that was first
identified in lipid tissue extracts. It has been classified as a CB2 receptor agonist …