Cytochrome P450 (CYP) family enzymes have a crucial role in detoxification of
environmental toxins which affected on male reproductive function. In this study we …

Aims: To investigate the correlation between the methylation status in the MDR1 promoter
region and the MDR1 genetic polymorphism. Methods: A total of 194 unrelated subjects …

Drug transporters are increasingly recognized as a key determinant of drug disposition and
response. The ATP-dependent efflux transporter, MDR1 (P-glycoprotein), has long been …

In vivo and in vitro studies have demonstrated that P-glycoprotein (P-gp) plays a very
significant role in the ADME processes (absorption, distribution, metabolism, excretion) and …

The three functional single-nucleotide polymorphisms (SNPs) of the MDR1 gene, C1236T,
G2677T/A, and C3435T, exhibit an interpopulation difference. In this study, we analyzed the …

Abstract Multidrug resistance 1 (MDR1) gene encodes the ATP-dependent cellular efflux
pump P-glycoprotein (P-gp) which efflux of a variety of substances across the membrane. P …

The study was designed to investigate the associations of polymorphisms Ile462Val and
3801T> C of the cytochrome P450 1A1 (CYP1A1) gene with idiopathic male infertility (IMI) …

Objective: The aim of this study was to investigate the association between genotype and
haplotype of MDR1 (C1236T, G2677T/A and C3435T) and the risk for cervical cancer in …

PURPOSE: To determine the role of glutathione S-transferases (GSTs; GSTM1, GSTT1, and
GSTP1) gene polymorphisms in susceptibility to male factor infertility. MATERIALS AND …

To explore the relationship between genetic polymorphisms of metabolic enzymes such as
CYP1A1, CYP2D6, GSTM1, GSTT1, and GSTP1 and idiopathic male infertility. By observing …