Objective: Preeclampsia (PE) belongs to main causes of mortality rates of mothers, fetuses
and new born children. Polymorphism of MDR1 gene is connected with reduction of P …

The ABC transporter P-glycoprotein is a product of the MDR1 gene and its function in human
placenta is to extrude xenobiotics from the tissue thus decreasing fetal exposure. The goal of …

The multidrug resistance gene (MDR1 or ABCB1) codes for P-glycoprotein, which plays an
important role in regulating absorption, distribution, and elimination of drugs. We examined …

Background: Several studies concerning the association between glutathione S-transferase
P1 (GSTP1) Ile105Val polymorphism and male infertility risk have reported controversial …

The aim of this study was to determine the genotype and allele frequencies of MDR1 gene
C3435T polymorphism in Jordanian and Sudanese populations, and to compare them with …

Two representative genetic variants of the MDR1 gene, 3435C> T and 2677G> T/A, show
wide interethnic differences in its genetic polymorphism. In this study, the authors evaluated …

Background P-glycoprotein, the product of the MDR1 gene, is a transmembrane active efflux
pump for a variety of environmental toxins and xenobiotics. Epidemiological studies have …

In the light of the relationship between the MDR1 G2677T polymorphism and the risk of
leukemia remains inclusive or controversial. For better understanding of the effect of MDR1 …

Background: The frequency of the multi-drug resistance 1 (MDR1) gene C3435T
polymorphism differs in various ethnical populations such as Asian, African, and Caucasians …

Human P-glycoprotein (P-gp) is encoded by the MDR1 gene, which is located on
chromosomal region 7q21 and consists of 28 exons. To date, over 50 single nucleotide …