The multi-drug resistance 1 (MDR1) gene encodes for a P-glycoprotein (PGP), which acts as
a gate-keeper against various kinds of xenobiotics. Several single nucleotide …

Background The MDR1 gene presents several genetic polymorphisms with pharmacological
implications. Therefore, the aim of the present study is to establish the genotype and allele …

OBJECTIVES: To investigate the genetic variability of multiple drug resistant 1 (MDR1) gene
C3435T polymorphism in four Southern Chinese populations. METHODS: Using …

Results: The genotype frequencies were: CC 32%(n= 85), CT 48%(n= 127) and TT 20%(n=
53). C and T allele frequencies were 0.56 and 0.44 respectively. The C allelic frequency for …

Department of Hematology, The First Affiliated Hospital, Henan University of Science and
Technology, Luoyang, China available. 2 authors examined the retrieved literature …

Abstract P-glycoprotein (PGP), the product of the multidrug resistance gene (MDR1), acts as
an energy-dependent efflux pump that exports its substrates out of the cell. PGP expression …

There exists a marked inter-individual variability of P-glycoprotein expression and activity,
which can be of clinical importance due to the large number of drugs that are substrates for …

Premature ejaculation (PE) is a common male sexual dysfunction disorder, and is
considered to have the genetic predisposition. However, the internal regulation mechanisms …

Pharmacogenomics is a rapidly developing field of biomedical research, which investigates
phenotypic and pharmacodynamic consequences of the genetic variations among …

The MDR1 multidrug transporter regulates the traffic of drugs, peptides and xenobiotics into
the body as well as sensitive tissues like the brain, germ cells and the developing fetus …