Previous studies indicated that the human multidrug resistance 1 gene (MDR1) is an
important candidate gene influencing the susceptibility to breast cancer. The purpose of this …

Sumamry Background: P‐glycoprotein (PgP) is the most extensively studied ATP‐binding
cassette (ABC) coded by MDR1 gene. To date, 29 single nucleotide polymorphisms (SNPs) …

Objective A role for the efflux transporter P-glycoprotein (P-gp), encoded by the MDR1
(ABCB1) gene, in human placenta is to protect the fetus from xenobiotics in the maternal …

Background. Many studies have assessed the relationship between gene polymorphisms in
multidrug resistance protein 3 (MDR3) and the risk of intrahepatic cholestasis of pregnancy …

Background: P-glycoprotein (P-gp), an ATP-dependent efflux pump, is a membrane protein
encoded by MDR1 gene. P-gp has an important role in protection of the cell against …

Abstract C1236T, G2677T/A, and C3435T polymorphism of the multidrug resistance (MDR1)
gene have substantial impact on expression or activity of P‐glycoprotein (P‐gp). We …

The aim of this study was to evaluate the most common ABCB1 (MDR1, P-glycoprotein)
polymorphisms in the population of R. Macedonia and compare the allele and haplotype …

The effects of the GST genes (GSTM1, GSTT1 and GSTP1) on male factor infertility have not
been well elucidated. A case–control study was performed to investigate the association …

Background and purpose: The human multidrug resistance gene (MDR1) encodes for P-
glycoprotein (P-gp) which is a transmembrane transporter protein acts as an efflux pump for …

Drug transporters are increasingly recognized to be important to drug disposition and
response. P‐glycoprotein, the encoded product of the human MDR1 (ABCB1) gene, is of …