The objective of this study was to develop a real-time polymerase chain reaction (PCR)
method to detect MDR1 (human multidrug resistance gene) single nucleotide …

P-glycoprotein (P-gp), the product of the MDR1 gene, shows large interindividual variations
in expression, which leads to differences in the pharmacokinetics of the substrate drugs. The …

Polycystic ovary syndrome is a multifactorial condition associated with reproductive and
endocrine organs and might cause infertility and metabolic abnormalities in childbearing …

Background Genes of different pathways regulate spermatogenesis, and the complexity of
the spermatogenic process indicates that polymorphisms or mutations in these genes could …

Infertility is a major issue at present and is a common disease that exists in both male and
female reproductive systems, described as failure to attain pregnancy. The most important …

Many genetic polymorphisms have been studied extensively to elucidate their role in the
pathophysiology of male infertility. This article presents a review of the literature following a …

The human multidrug resistance gene (MDR1) encodes for P-glycoprotein (P-gp) which is a
transmembrane transporter protein that acts as an efflux pump for a number of lypophilic …

Background: One of the limitations in the treatment of common diseases such as cancer
chemotherapy is development of multidrug resistance (MDR). Polymorphisms could alter the …

The multidrug resistance gene (MDR1) plays an important role in the transport of a wide
range of drugs and elimination of xenobiotics from the body. Identification of polymorphisms …

The human multidrug resistance gene 1 (MDR1) encodes a plasma membrane, P-
glycoprotein (Pgp), which functions as the transmembrane efflux pump for various …