In this Special Series issue, Journal of Clinical Oncologypresents a systematic assessment
of cancer genomic information and its accelerating clinical impact. In the scientific literature …

Molecular characterization of tumors has shifted cancer treatment strategies away from
nonspecific cytotoxic treatment of histology-specific tumors toward targeting of actionable …

The Human Genome Project not only provided the essential reference map for the human
genome but also stimulated the development of technology and analytic tools to process …

Our understanding of the molecular mechanisms underlying cancer development and
evolution have evolved rapidly over recent years, and the variation from one patient to …

Molecular profiling in precision medicine oncology | Nature Medicine Skip to main content
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Based on early evidence of fossilized bone tumors that were found in ancient Egyptian
mummies, cancer is an ancient disease. 1 The term “carcinoma7 to refer to cancer was first …

Current efforts in precision oncology largely focus on the benefit of genomics-guided
therapy. Yet, advances in sequencing techniques provide an unprecedented view of the …

With the increasing use of genomic profiling for diagnosis and therapy guidance in many
tumor types, precision oncology is rapidly reshaping cancer care. However, the current …

In recent years, biotechnological breakthroughs have led to identification of complex and
unique biologic features associated with carcinogenesis. Tumor and cell-free DNA profiling …

Precision diagnostics is one of the two pillars of precision medicine. Sequencing efforts in
the past decade have firmly established cancer as a primarily genetically driven disease …