RNA splicing is a fundamental regulatory process of gene expression and plays a pivotal
role in transcriptome complexity, cell-fate determination, and organism development. The …

Alternative splicing of RNAs generates isoform diversity, resulting in different proteins that
are necessary for maintaining cellular function and identity. The discovery of alternative …

Alternative splicing is an important source of heterogeneity underlying gene expression
between individual cells but remains an understudied area due to the paucity of …

Alternative mRNA splicing is a rich source of transcript diversity in eukaryotic cells with
broad roles in development and disease. Systems-wide experimental methods have started …

Most human messenger RNAs (mRNAs) are alternatively spliced and many exhibit disease-
specific splicing patterns. However, the contribution of most splicing events to the …

Splicing factors play an essential role in regulation of alternative pre-mRNA splicing. While
much progress has been made in delineating the mechanisms of the splicing machinery, the …

As a fundamental aspect of normal cell signaling and disease states, there is great interest
in determining alternative splicing (AS) changes in physiologic, pathologic, and …

Since the discovery of RNA splicing in 1977 the knowledge of this important biological
process has increased steadily following the identification of many of the mechanistic …

Alternative splicing is a powerful mechanism present in eukaryotic cells to obtain a wide
range of transcripts and protein isoforms from a relatively small number of genes. The …

Alternative splicing plays an essential role in many cellular processes and bears major
relevance in the understanding of multiple diseases, including cancer. High-throughput RNA …