To gain more detailed insight into the nature and mechanisms of spontaneous mutations, we
undertook a DNA sequence analysis of a large collection of spontaneous mutations in the N …

We have obtained via DNA sequence analysis a spectrum of 174 spontaneous mutations
occurring in the lacI gene of Escherichia coli. The spectrum comprised base substitution …

We have determined the DNA sequence changes in 487 spontaneous mutations in the N-
terminal part of the lacI gene in mutH, mutL, and mutS strains of Escherichia coli. These …

We used the lacI system of Escherichia coli to examine the distribution of base substitution
mutations occurring spontaneously in different mismatch-repair-deficient strains. The …

This paper describes the DNA sequence analysis of 729 independent spontaneous lacI−
mutation This total is comprised of 478 novel mutations and 251 previously described …

Abstract 140 independently occurring spontaneous mutations in the lacI gene of Escherichia
coli have been examined genetically and physically. DNA sequence analysis of a genetic …

Nonsense mutations derived from 90 different codons in the lacI gene of Escherichia coli
have been correlated with the I gene nucleotide sequence. In over 80 cases the specific …

To determine whether base-to-base variations in the rate of excision repair influence the
distribution of mutations, we have developed a method to measure UV photoproducts at …

Transgenic mice with a lambda shuttle vector containing a lacI target gene were generated
for use as a short-term, in vivo mutagenesis assay. The gene is recovered from the treated …

A genetic and sequence analysis of 373 ICR-191-induced mutations in the lacI gene of
Escherichia coli reveals that 365 of the mutations (97· 9%) are frameshifts involving the …