A selenium containing inhibitor for the treatment of hepatocellular cancer
Hepatocellular carcinoma (HCC) is the third most deadly cancer in the world. New treatment
strategies are desperately needed due to limited standard therapies. Activation of the Erk …
strategies are desperately needed due to limited standard therapies. Activation of the Erk …
PBISe, a novel selenium-containing drug for the treatment of malignant melanoma
SRV Madhunapantula, D Desai, A Sharma… - Molecular cancer …, 2008 - AACR
Malignant melanoma is the most deadly form of skin cancer due to its highly metastatic
nature. Untargeted therapies are ineffective for treating metastatic disease, leading to the …
nature. Untargeted therapies are ineffective for treating metastatic disease, leading to the …
[HTML][HTML] Antitumor activity of selenium in Ehrlich ascites carcinoma bearing mice
J Hussein, Z El-khayat… - Biomedical and …, 2023 - biomedpharmajournal.org
The most common disease states of chronic liver illnesses include alcoholic liver disease
(ALD), and viral hepatitis can progress to hepatocellular carcinoma (HCC). However, the …
(ALD), and viral hepatitis can progress to hepatocellular carcinoma (HCC). However, the …
Selenium donor inhibited hepatitis B virus associated hepatotoxicity via the apoptosis and ferroptosis pathways
J Shi, Z Liu, W Li, D Wang - Analytical Cellular Pathology, 2023 - Wiley Online Library
Background and Aim. Selenium possesses anticancer and antiviral properties, but its
mechanism of action remains unclear. Especially, the impact of selenium on hepatitis B virus …
mechanism of action remains unclear. Especially, the impact of selenium on hepatitis B virus …
Evaluation of selenite effects on selenoproteins and cytokinome in human hepatoma cell lines
F Rusolo, B Pucci, G Colonna, F Capone, E Guerriero… - Molecules, 2013 - mdpi.com
The need to explore new alternative therapeutic strategies and chemoprevention methods
for hepatocellular carcinoma is growing significantly. Selenium is a trace element that plays …
for hepatocellular carcinoma is growing significantly. Selenium is a trace element that plays …
[HTML][HTML] Oxygen therapy accelerates apoptosis induced by selenium compounds via regulating Nrf2/MAPK signaling pathway in hepatocellular carcinoma
C Wang, T Cheng, Q Lu, W Li, B Liu, L Yue… - Pharmacological …, 2023 - Elsevier
Selenium has good antitumor effects in vitro, but the hypoxic microenvironment in solid
tumors makes its clinical efficacy unsatisfactory. We hypothesized that the combination with …
tumors makes its clinical efficacy unsatisfactory. We hypothesized that the combination with …
[HTML][HTML] Butaselen prevents hepatocarcinogenesis and progression through inhibiting thioredoxin reductase activity
Hepatocellular carcinoma (HCC) accounts for most of primary liver cancer, of which five-year
survival rate remains low and chemoprevention has become a strategy to reduce disease …
survival rate remains low and chemoprevention has become a strategy to reduce disease …
Selenite-induced survival of HuH7 hepatoma cells involves activation of focal adhesion kinase-phosphatidylinositol 3-kinase-Akt pathway and Rac1
YC Lee, YC Tang, YH Chen, CM Wong… - Journal of Biological …, 2003 - ASBMB
Selenium has been shown to sustain the growth of selected human hepatocellular
carcinoma cell lines under serum-free conditions, but the detailed mechanism remained …
carcinoma cell lines under serum-free conditions, but the detailed mechanism remained …
[HTML][HTML] Selenium in the prevention and treatment of hepatocellular carcinoma: from biomedical investigation to clinical application
CS Cheng, N Wang, Y Feng - … of Selenium in the Environment and …, 2019 - intechopen.com
Selenium is a micronutrient that had been suggested to reduce the risk of cancer.
Hepatocellular carcinoma (HCC), a prevalent disease and one of the most lethal cancers in …
Hepatocellular carcinoma (HCC), a prevalent disease and one of the most lethal cancers in …
AMPK interacts with β-catenin in the regulation of hepatocellular carcinoma cell proliferation and survival with selenium treatment
SY Park, YK Lee, HJ Kim, OJ Park… - Oncology …, 2016 - spandidos-publications.com
Selenium has received much attention as an anticancer agent, although the mechanisms of
action underlying its pro-apoptotic properties remain unclear. Tumors that respond well to …
action underlying its pro-apoptotic properties remain unclear. Tumors that respond well to …