Atherosclerosis is a multifactorial highly-complex disease with numerous etiologies that
work synergistically to promote lesion development. The ability to develop preventive and …

Although atherosclerosis was previously thought to be mainly a degenerative disease, it is
now well ascertained that its pathogenesis is inflammatory. There was a pivotal role of apoE …

Hyperlipidemia is the most important risk factor for atherosclerosis, which is the major cause
of cardiovascular disease. The etiology of hyperlipidemia and atherosclerosis is complex …

An ideal animal model of atherosclerosis resembles human anatomy and pathophysiology
and has the potential to be used in medical and pharmaceutical research to obtain results …

Murine models of atherosclerosis are useful for investigating the environmental and genetic
influences on lesion formation and composition. Apoe−/− and Ldlr−/− mice are the 2 most …

In this mini-review several commonly used animal models of atherosclerosis have been
discussed. Among them, emphasis has been made on mice, rabbits, pigs and non-human …

This review discusses the application-side of using mice as an animal model of
atherosclerosis, and is directed towards the researcher new to using mice to perform …

Atherosclerosis is a complex, multifactorial disease with both genetic and environmental
determinants. Experimental investigation of the effects of these determinants on the …

Since 1992 the mouse has become an excellent model for experimental atherosclerosis
research. Until 1992, the diet-induced atherosclerosis mouse model has been used …

Since the early 1990s, several strains of genetically modified mice have been developed as
models for experimental atherosclerosis. Among the available models, the apolipoprotein E …