In the last two decades several significant changes have been proposed in the receptor
theory that describes how ligands can interact with G protein‐coupled receptors (GPCRs) …

The mechanisms behind the long duration of bronchodilating action of the β 2-adrenoceptor
agonists formoterol and salmeterol are only partially understood. This review compares …

If asthma is not controlled with low-dose inhaled corticosteroids (ICS), by far the best next
step is the addition of a long-acting, inhaled beta-agonist (LABA). Questions regarding the …

The aim of this study was to systematically compare the interaction of the long-acting beta2-
adrenoceptor agonists formoterol and salmeterol with short-acting beta2-adrenoceptor …

The preclinical pharmacological profile of 6-hydroxy-8-[(1 R)-1-hydroxy-2-[[2-(4-
methoxyphenyl)-1, 1-dimethylethyl] amino] ethyl]-2 H-1, 4-benzoxazin-3 (4 H)-one …

Aims Inhalers combining long acting β2‐adrenoceptor agonists (LABA) and corticosteroids
(ICS) are indicated at Step 3 of current asthma guidelines. We evaluated the relative effects …

Background Safety concerns regarding long-acting β2-agonists (LABAs) in asthma
management were initially identified in a large postmarketing trial in which the risk of death …

Role of long-acting β2-adrenergic agonists in asthma managem... : Current Opinion in
Pulmonary Medicine Role of long-acting β2-adrenergic agonists in asthma management based …

For the last three decades, the guidelines for asthma management have supported a
stepwise therapeutic approach, based on the administration of controller medications …

A series of dibasic des-hydroxy β2 receptor agonists has been prepared and evaluated for
potential as inhaled ultralong acting bronchodilators. Determination of activities at the …