Background There is some evidence that sleep deprivation (SD) might exert its
antidepressant properties by involving serotonergic mechanisms. We investigated the …

Rationale: Recently, a number of studies have challenged the finding that acute tryptophan
depletion (TD) increases depressive symptoms in medicated, formerly depressed patients …

BACKGROUND: Mood sensitivity to rapid tryptophan depletion (RTD) has been
demonstrated in patients treated with antidepressants that act preferentially on the …

Background: Previous studies show that rapid tryptophan depletion reverses the effects of
therapy with serotonergic, but not noradrenergic, antidepressant drugs in patients with …

Background: The number of studies using tryptophan depletion (TD) challenge has
increased markedly in the past few years. Recently, a number of negative results have been …

Objective: Brain serotonin systems might be involved in the pathophysiology of seasonal
affective disorder. The authors tested whether tryptophan depletion alters the mood of …

The tryptophan depletion test is a research strategy to investigate the functional
consequences of decreasing the brain serotonin metabolism. Because serotonin is involved …

Background In previous studies, depletion of brain serotonin by administration of a
tryptophan-free amino acid drink (TFD)(1) temporarily reversed the antidepressant effects of …

It has frequently been demonstrated that acute tryptophan depletion (ATD) induces a
transient depressed mood in some patients who are in remission from depression. However …

Background. Deficiencies in brain serotonin function are believed to play an important role
in the pathophysiology of seasonal affective disorder/winter type (SAD). However, no direct …