Background Human g rowth factor r eceptor b ound protein 7 (Grb7) is an adapter protein
that mediates the coupling of tyrosine kinases with their downstream signaling pathways …

Growth-receptor-bound protein (Grb) 7 is an adapter protein aberrantly overexpressed,
along with the erbB-2 receptor in breast cancer and in other cancers. Normally recruited to …

Grb7 is an adapter protein involved in the propagation of signals in cancer cell migration
and proliferation, and is thus a target for the development of novel anti‐cancer agents. An 11 …

G7‐18NATE is a nonphosphorylated, cyclic peptide that specifically inhibits the Grb7
adapter protein implicated in several pathways critical to cell proliferation and migration. It …

Grb7 is a signaling protein with critical roles in tumor cell proliferation and migration and an
established cancer therapeutic target. Here we explore chemical space to develop a new …

Src‐homology (SH2) domains are an attractive target for the inhibition of specific signalling
pathways but pose the challenge of developing a truly specific inhibitor. The G7‐18NATE …

Grb7 is an adapter-type signaling protein, which is recruited via its SH2 domain to a variety
of receptor tyrosine kinases (RTKs), including ErbB2 and ErbB3. It is overexpressed in …

Grb7 is an adapter protein found to be overexpressed in several breast and other cancer cell
types along with ErbB2. Grb7 is normally an interaction partner with focal adhesion kinase …

Growth factor receptor bound protein 7 (Grb7) is an adapter protein that functions as a
downstream effector of growth factor mediated signal transduction. Over-expression of Grb7 …

Grb7 is a non‐catalytic protein, the overexpression of which has been associated with the
proliferative and migratory potentials of cancer cells. Virtual screening strategies involving a …