Ligand binding and functional effects of systematic double d-amino acid residue substituted neuropeptide Y analogs on Y1 and Y2 receptor types

L Grundemar, U Kahl, T Callréus, Ü Langel… - Regulatory peptides, 1996 - Elsevier
In order to identify the signal epitopes of the neuropeptide Y (NPY) molecule, the
conformation of the NPY molecule was pertubated by a systematic double d-amino acid …

Neuropeptide Y receptor binding sites in rat brain: differential autoradiographic localizations with 125I-peptide YY and 125I-neuropeptide Y imply receptor …

DR Lynch, MW Walker, RJ Miller… - Journal of …, 1989 - Soc Neuroscience
Neuropeptide Y (NPY) receptor binding sites have been localized in the rat brain by in vitro
autoradiography using picomolar concentrations of both 125I-NPY and 125I-peptide YY …

[PDF][PDF] Neuropeptide Y and the nonpeptide antagonist BIBP 3226 share an overlapping binding site at the human Y1 receptor.

M Sautel, K Rudolf, H Wittneben, H Herzog… - Molecular …, 1996 - Citeseer
Neuropeptide V (NPY) is a 36-amino acid peptide that exhibits actions on the cardiovascular
system and the central nervous system. NPY can regulate blood pressure, psychomotor func …

[引用][C] Neuropeptide Y Receptors: Autoradiographic Distribution in the Brain and Structure‐Activity Relationships a

R Quirion, JC MARTEL, Y Dumont… - Annals of the New …, 1990 - Wiley Online Library
Following the isolation of neuropeptide Y (NPY) and related peptides (such as PYY) by
Tatemoto and colleague^,'-^ it rapidly became evident that these substances possess …

Peptide antagonists of neuropeptide Y: Design, structure and pharmacological characterization

AJ Daniels, D Heyer, A Spaltenstein - Neuropeptide Y and drug …, 1997 - Elsevier
Publisher Summary This chapter discusses design, structure, and pharmacological
characterization of peptide antagonists of neuropeptide. The structure-affinity pattern found …

Cloning and characterization of neuropeptide Y receptors of the Y1 subfamily in mammals and fish

P Starbäck - 2000 - diva-portal.org
Cloning and Characterization of Neuropeptide Y receptors of the Y1 Subfamily in Mammals
and Fish Page 1 Comprehensive Summaries of Uppsala Dissertations from the Faculty of …

Characterization of a selective antagonist of neuropeptide Y at the Y2 receptor. Synthesis and pharmacological evaluation of a Y2 antagonist.

E Grouzmann, T Buclin, M Martire, C Cannizzaro… - Journal of Biological …, 1998 - ASBMB
The T4-[NPY (33–36)] 4 used in the paper has the structure indicated as in Figs. 1 and 2.
The experiments depicted in Figs. 4, 5, 6, and 7 as well as Tables I and II also used the …

[HTML][HTML] Cloning and functional expression of a human neuropeptide Y/peptide YY receptor of the Y1 type.

D Larhammar, AG Blomqvist, F Yee, E Jazin… - Journal of Biological …, 1992 - Elsevier
Neuropeptide Y (NPY) and peptide YY (PYY) are structurally related peptides that primarily
function as neurotransmitter and gastrointestinal hormone, respectively. Previous functional …

Actions of neuropeptide Y on peripheral and central targets: Characterization of receptor subtypes.

LA Grundemar - 1993 - elibrary.ru
Degree: Fil. Dr. DegreeYear: 1991 Institute: Lunds Universitet (Sweden) Publisher: Graphic
Systems Ab, N. Grangesbergs. Co. 19, Box 130 14, Malmo, Sweden. Neuropeptide Y (NPY) …

Y1 and Y2 receptors for neuropeptide Y

SP Sheikh, R Håkanson, TW Schwartz - FEBS letters, 1989 - Wiley Online Library
By using monoiodinated radioligands of both intact neuropeptide Y (NPY) and of a long C‐
terminal fragment, NPY13–36, two subtypes of binding sites, which differ in affinity and …