The mismatch repair system is involved in the maintenance of genomic integrity by editing
DNA replication and recombination. However, although most mutations are neutral or …

In vivo experiments with heteroduplex lambda genomes show that the MutY mismatch repair
system of Escherichia coli defines an average repair tract that is shorter than 27 nucleotides …

Escherichia coli mutT strains are strong mutators yielding only A· T→ C· G transversion
mutations. These are thought to result from uncorrected (or unprevented) A· G mispairings …

ABSTRACT mutS mutators accelerate the bacterial mutation rate 100-to 1,000-fold and relax
the barriers that normally restrict homeologous recombination. These mutators thus afford …

Using site-specific mutagenesis in vitro we constructed a genetic system to detect mutants
with altered rates of deletion formation between short repeated sequences in Escherichia …

A minor population of wild Escherichia coli strains contain retroelements called retrons,
which produce a peculiar satellite DNA, multicopy single-stranded DNA (msDNA). It has …

We have constructed heteroduplex plasmid DNA that is similar in structure to the
heteroduplex DNA expected to be produced during genetic recombination of plasmids, and …

A Lac-strain of Escherichia coli that reverts by the addition of a G to a GGGGGG sequence
was used to study the proliferation of mutators in a bacterial culture. Selection for the Lac+ …

The mutL gene product is part of the dam-directed mismatch repair system of Escherichia
coli but has no known enzymatic function. It forms a complex on heteroduplex DNA with the …

Six different base-pair transversion mismatches are repaired with different efficiencies in an
in vitro mismatch repair system. In particular, the T/T and C/C mismatches appear to be less …