In one experimental system, several handles on the molecular mechanism of apparent
adaptive mutation have emerged. The system is reversion of a lac frame‐shift mutation in …

Previous biochemical analysis ofEscherichia coli methyl-directed mismatch repair implicates
three redundant single-strand DNA-specific exonucleases (RecJ, ExoI, and ExoVII) and at …

DNA mismatch repair in Escherichia coli has been shown to be involved in two distinct
processes: mutation avoidance, which removes potential mutations arising as replication …

The sequences of adaptive reversions of a lac frameshift mutation in Escherichia coli
resemble DNA polymerase errors, and the adaptive reversions decrease in strains with an …

We show that the MutY protein competes with the MutS-dependent mismatch repair system
to process at least some A· C mispairs in vivo, converting them to G· C pairs. In the presence …

The Escherichia coli mismatch repair system greatly improves DNA replication fidelity by
repairing single mispaired and unpaired bases in newly synthesized DNA strands. Transient …

The ability of related DNAs to undergo recombination decreases with increased sequence
divergence. Mismatch repair has been proposed to be a key factor in preventing …

The mutD (dnaQ) gene of Escherichia coli codes for the epsilon subunit of the DNA
polymerase III holoenzyme which is involved in 3'----5'exonuclease proofreading activity. We …

In 1964 Robin Holliday (1) proposed the correction of DNA base pair mismatches within
recombination intermediates as the basis for gene conversion. The existence of the …

The mutB gene of Salmonella typhimurium is involved in a methylation-independent repair
pathway specific for A/G or A/C mismatches and is the homolog of the Escherichia coli mutY …