Diabetes is a complex metabolic syndrome that is characterized by prolonged high blood
glucose levels and frequently associated with life-threatening complications …

Activation of the PTEN–PI3K–mTORC1 pathway consolidates metabolic programs that
sustain cancer cell growth and proliferation,. Here we show that mechanistic target of …

The tumour suppressor TP53 is mutated in the majority of human cancers, and in over 70%
of pancreatic ductal adenocarcinoma (PDAC),. Wild-type p53 accumulates in response to …

Metformin, the most prescribed antidiabetic medicine, has shown other benefits such as anti-
ageing and anticancer effects,,–. For clinical doses of metformin, AMP-activated protein …

Metabolic reprogramming is a hallmark of cancer. Herein we discover that the key glycolytic
enzyme pyruvate kinase M2 isoform (PKM2), but not the related isoform PKM1, is methylated …

The discovery of cancer dependencies has the potential to inform therapeutic strategies and
to identify putative drug targets. Integrating data from comprehensive genomic profiling of …

Hypermethylation of the promoters of tumour suppressor genes represses transcription of
these genes, conferring growth advantages to cancer cells. How these changes arise is …

Understanding cellular metabolism holds immense potential for developing new classes of
therapeutics that target metabolic pathways in cancer. Metabolic pathways are altered in …

Activation of cellular stress response pathways to maintain metabolic homeostasis is
emerging as a critical growth and survival mechanism in many cancers. The pathogenesis of …

Cancer cells exhibit several unique metabolic phenotypes that are critical for cell growth and
proliferation. Specifically, they overexpress the M2 isoform of the tightly regulated enzyme …