Anti-arrhythmic and inotropic effects of empagliflozin following myocardial ischemia
MA Azam, P Chakraborty, D Si, BB Du, S Massé… - Life sciences, 2021 - Elsevier
Background Empagliflozin (EMPA) reduces heart failure hospitalization and mortality. The
benefit in terms of ventricular arrhythmia and contractility has not been explored. Objective …
benefit in terms of ventricular arrhythmia and contractility has not been explored. Objective …
Empagliflozin Reverses Late Na+ Current Enhancement and Cardiomyocyte Proarrhythmia in a Translational Murine Model of Heart Failure With Preserved Ejection …
B Hegyi, J Mira Hernandez, EY Shen, NR Habibi… - Circulation, 2022 - Am Heart Assoc
Empagliflozin, a sodium-glucose cotransporter-2 inhibitor, has been recently shown to
improve cardiovascular outcomes in patients who have heart failure with preserved ejection …
improve cardiovascular outcomes in patients who have heart failure with preserved ejection …
Cardioprotective effects of empagliflozin after ischemia and reperfusion in rats
JM Seefeldt, TR Lassen, MV Hjortbak, NR Jespersen… - Scientific Reports, 2021 - nature.com
Abstract The Sodium Glucose Co-Transporter-2 inhibitor, empagliflozin (EMPA), reduces
mortality and hospitalisation for heart failure following myocardial infarction irrespective of …
mortality and hospitalisation for heart failure following myocardial infarction irrespective of …
Sodium–Glucose cotransporter 2 inhibitor empagliflozin decreases ventricular arrhythmia susceptibility by alleviating electrophysiological remodeling post-myocardial …
G Xue, X Yang, G Zhan, X Wang, J Gao… - Frontiers in …, 2022 - frontiersin.org
Background: Recent clinical trials indicate that sodium–glucose cotransporter 2 (SGLT2)
inhibitors improve cardiovascular outcomes in myocardial infarction (MI) patients, but the …
inhibitors improve cardiovascular outcomes in myocardial infarction (MI) patients, but the …
Empagliflozin protects the heart against ischemia/reperfusion-induced sudden cardiac death
Z Hu, F Ju, L Du, GW Abbott - Cardiovascular diabetology, 2021 - Springer
Background Empagliflozin is a selective sodium–glucose cotransporter 2 (SGLT2) inhibitor
used to lower blood sugar in adults with type 2 diabetes. Empagliflozin also exerts …
used to lower blood sugar in adults with type 2 diabetes. Empagliflozin also exerts …
Sodium–glucose co‐transporter 2 inhibition with empagliflozin improves cardiac function in non‐diabetic rats with left ventricular dysfunction after myocardial infarction
SR Yurista, HHW Silljé… - European journal of …, 2019 - Wiley Online Library
Aims Sodium–glucose co‐transporter 2 (SGLT2) inhibition reduces heart failure
hospitalizations in patients with diabetes, irrespective of glycaemic control. We examined the …
hospitalizations in patients with diabetes, irrespective of glycaemic control. We examined the …
Load-independent effects of empagliflozin contribute to improved cardiac function in experimental heart failure with reduced ejection fraction
KA Connelly, Y Zhang, JF Desjardins, L Nghiem… - Cardiovascular …, 2020 - Springer
Background and aims Sodium–glucose linked cotransporter-2 (SGLT2) inhibitors reduce the
likelihood of hospitalization for heart failure and cardiovascular death in both diabetic and …
likelihood of hospitalization for heart failure and cardiovascular death in both diabetic and …
Empagliflozin directly improves diastolic function in human heart failure
S Pabel, S Wagner, H Bollenberg… - European journal of …, 2018 - Wiley Online Library
Aims Empagliflozin, a clinically used oral antidiabetic drug that inhibits the sodium‐
dependent glucose co‐transporter 2, has recently been evaluated for its cardiovascular …
dependent glucose co‐transporter 2, has recently been evaluated for its cardiovascular …
Empagliflozin reduces Ca/calmodulin‐dependent kinase II activity in isolated ventricular cardiomyocytes
J Mustroph, O Wagemann, CM Lücht, M Trum… - ESC heart …, 2018 - Wiley Online Library
Abstract Aims The EMPA‐REG OUTCOME study showed reduced mortality and
hospitalization due to heart failure (HF) in diabetic patients treated with empagliflozin …
hospitalization due to heart failure (HF) in diabetic patients treated with empagliflozin …
Empagliflozin prevents from early cardiac injury post myocardial infarction in non-diabetic mice
Y Liu, M Wu, J Xu, B Xu, L Kang - European Journal of Pharmaceutical …, 2021 - Elsevier
Objectives Sodium-glucose cotransporter 2 (SGLT2) inhibitors have been confirmed to
reduce the rate of rehospitalization for heart failure and cardiovascular death in diabetic …
reduce the rate of rehospitalization for heart failure and cardiovascular death in diabetic …