Aberrant protein glycosylation in cancer: implications in targeted therapy
Aberrant cell surface glycosylation signatures are currently known to actively drive the
neoplastic transformation of healthy cells. By disrupting the homeostatic functions of their …
neoplastic transformation of healthy cells. By disrupting the homeostatic functions of their …
Glycosylation in the era of cancer-targeted therapy: where are we heading?
S Mereiter, M Balmaña, D Campos, J Gomes, CA Reis - Cancer cell, 2019 - cell.com
This review provides insights on the impact of glycosylation in cancer biology and its
influence in the current approaches of targeted cancer therapies in the clinical setting. The …
influence in the current approaches of targeted cancer therapies in the clinical setting. The …
Protein glycosylation and tumor microenvironment alterations driving cancer hallmarks
Decades of research have disclosed a plethora of alterations in protein glycosylation that
decisively impact in all stages of disease and ultimately contribute to more aggressive cell …
decisively impact in all stages of disease and ultimately contribute to more aggressive cell …
Targeting glycosylation: a new road for cancer drug discovery
Cancer is a deadly disease that encompasses numerous cellular modifications. Among
them, alterations in glycosylation are a proven reliable hallmark of cancer, with most …
them, alterations in glycosylation are a proven reliable hallmark of cancer, with most …
[HTML][HTML] Hallmarks of glycosylation in cancer
J Munkley, DJ Elliott - Oncotarget, 2016 - ncbi.nlm.nih.gov
Aberrant glycosylation plays a fundamental role in key pathological steps of tumour
development and progression. Glycans have roles in cancer cell signalling, tumour cell …
development and progression. Glycans have roles in cancer cell signalling, tumour cell …
Altered glycosylation in cancer: A promising target for biomarkers and therapeutics
Glycosylation is a well-regulated cell and microenvironment specific post-translational
modification. Several glycosyltransferases and glycosidases orchestrate the addition of …
modification. Several glycosyltransferases and glycosidases orchestrate the addition of …
Glycosylation in cancer: mechanisms and clinical implications
Despite recent progress in understanding the cancer genome, there is still a relative delay in
understanding the full aspects of the glycome and glycoproteome of cancer. Glycobiology …
understanding the full aspects of the glycome and glycoproteome of cancer. Glycobiology …
The sweet side of immune evasion: role of glycans in the mechanisms of cancer progression
AFFR Nardy, L Freire-de-Lima… - Frontiers in …, 2016 - frontiersin.org
Glycans are part of the essential components of a cell. These compounds play a
fundamental role in several physiopathological processes, including cell differentiation …
fundamental role in several physiopathological processes, including cell differentiation …
Protein glycosylation in gastric and colorectal cancers: Toward cancer detection and targeted therapeutics
JA Ferreira, A Magalhaes, J Gomes, A Peixoto… - Cancer letters, 2017 - Elsevier
Glycosylation is the most frequent and structurally complex posttranslational modification in
cell-surface and secreted proteins. Glycans are major orchestrators of biological processes …
cell-surface and secreted proteins. Glycans are major orchestrators of biological processes …
[HTML][HTML] Roles of glycosylation at the cancer cell surface: opportunities for large scale glycoproteomics
Cell surface glycosylation has a variety of functions, and its dysregulation in cancer
contributes to impaired signaling, metastasis and the evasion of the immune responses …
contributes to impaired signaling, metastasis and the evasion of the immune responses …
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