A drug's aqueous solubility is defined as the ability to dissolve in a particular solvent, and it
is currently a major hurdle in bringing new drug molecules to the market. According to some …

Among all newly discovered chemical entities about 40% drugs are lipophillic and fail to
reach market due to their poor aqueous solubility. For orally administered drugs solubility is …

One of the most important parameters in pharmacy is drug solubility. Solubility affects the
efficacy of a drug. Drug solubility has an important role in determining the concentration of a …

The low water solubility of pharmacoactive molecules limits their pharmacological potential,
but the solubility parameter cannot compromise, and so different approaches are employed …

Solubility is not to be confused with the ability to dissolve or liquefy a substance, since this
process may occur not only because of dissolution but also because of a chemical reaction …

Introduction: For poorly soluble compounds, a good bioavailability is typically needed to
assess the therapeutic index and the suitability of the compound for technical development …

Drugs with low water solubility are predisposed to low and variable oral bioavailability and,
therefore, to variability in clinical response. Despite significant efforts to “design in” …

The solubility behavior of drugs remains one of the most exigent aspects in formulation
development. With the advent of combinatorial chemistry and high throughput screening, the …

ABSTRACT A success of formulation depends on how efficiently it makes the drug available
at the site of action. Therapeutic effectiveness of a drug depends upon the bioavailability …

A wide variety of new medication disclosures launched by specific benefits of the general
public are laced with poor aqueous solubility problems that often obstruct their bioavailability …