Recently, a novel technique named the clustered regularly interspaced short palindromic
repeat (CRISPR)/CRISPR‐associated protein (Cas) 9 system has been rapidly developed …

ABSTRACT The Type II CRISPR‐Cas9 system is a simple, efficient, and versatile tool for
targeted genome editing in a wide range of organisms and cell types. It continues to gain …

Genome editing, which involves the precise manipulation of cellular DNA sequences to alter
cell fates and organism traits, has the potential to both improve our understanding of human …

Programmable DNA cleavage using CRISPR–Cas9 enables efficient, site-specific genome
engineering in single cells and whole organisms. In the research arena, versatile CRISPR …

Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) provides acquired
immunity in microorganisms against exogenous DNA that may hinder the survival of the …

Conspectus The discovery of CRISPR/Cas has revolutionized the field of genome editing.
CRIPSR/Cas components are part of the bacterial immune system and are able to induce …

The CRISPR-Cas systems have shown tremendous promise as heterologous tools for
genome editing in various prokaryotes. However, the perturbation of DNA homeostasis and …

Adaptive T-cell immunotherapy holds great promise for the successful treatment of leukemia,
as well as other types of cancers. More recently, it was also shown to be an effective …

While human gene therapy has gained significant attention for its therapeutic promise,
CRISPR/Cas9 technology has made a breakthrough as an efficient genome editing tool by …

Clustered regularly interspaced short palindromic repeats (CRISPR)‐Cas adaptive immune
defense systems, which are widely distributed in bacteria and Archaea, can provide …