While extended infusions of piperacillin-tazobactam (TZP) are increasingly used in practice,
the effect of infusion on the pharmacokinetic (PK) profile of TZP has not been widely …

The primary objectives of this analysis were to determine which pharmacokinetic model
most accurately describes the elimination pathways for piperacillin in the presence of …

The objective of this study was to evaluate the steady-state pharmacokinetics and
pharmacodynamics of piperacillin/tazobactam, administered by prolonged infusion, in …

Background: Prolonging the infusion of a β-lactam antibiotic enhances the time in which
unbound drug concentrations remain above the minimum inhibitory concentration (fT> MIC) …

Piperacillin-tazobactam is a potent β-lactam/β-lactamase inhibitor antibiotic commonly
prescribed in the intensive care unit setting. Admitted patients often show large variability in …

The study objective was to evaluate the population pharmacokinetics and
pharmacodynamics of extended-infusion piperacillin-tazobactam in children hospitalized in …

In the present study 24 hospitalized patients requiring empirical antibiotic treatment were
randomly assigned to receive the β-lactam antibiotic/β-lactamase inhibitor combination …

Importance of the field: Piperacillin-tazobactam is a frequently prescribed intravenous
antibiotic for moderate to severe infections used in hospital settings because of its broad …

The percentage of the time that the free drug concentration remains above a concentration
threshold (% fT> concentration threshold) has frequently been identified to be the optimal …

Background: Although intermittent bolus dosing is currently the standard of practice for many
antimicrobial agents, beta-lactams exhibit time-dependent bacterial killing. Maximizing the …