Interleukins represent a class of immunomodulatory cytokines, small intercellular signaling
proteins, that are critically involved in the regulation of immune responses. They are …

Chronic liver injury with any etiology can progress to fibrosis and the end-stage diseases
cirrhosis and hepatocellular carcinoma. The progression of liver disease is controlled by a …

Summary Interleukin 6 (IL-6) is a pleiotropic four-helix-bundle cytokine that exerts multiple
functions in the body. In the liver, IL-6 is an important inducer of the acute phase response …

The gene encoding IL‐1 was sequenced more than 30 years ago, and many related
cytokines, such as IL‐18, IL‐33, IL‐36, IL‐37, IL‐38, IL‐1 receptor antagonist (IL‐1Ra), and …

Liver pathologies (fibrosis, cirrhosis, alcoholic, non-alcoholic diseases and hepatocellular
carcinoma) represent one of the most common causes of death worldwide. A number of …

The pyrogenic property being the first activity described, members of the interleukin-1
superfamily (IL-1α, IL-1β, IL-18, and the newest members: IL-33, IL-36, IL-37, and IL-38) are …

ABSTRACT The interleukin 6 (IL6) family of proteins regulate important cellular processes
and act through a variety of signaling pathways via a shared gp130 receptor. In the liver …

The liver is a major metabolic organ and an immunologically complex organ. It produces
and uses many substances such as acute phase proteins, cytokines, chemokines, and …

Cytokines are extracellular proteins involved in the regulation of innate and immunologically
inflammatory reactions. These proteins are involved in various processes including cell …

Cytokines comprise a group of small proteins released from cells in order to influence the
function of other cells. By binding to highly specific cell-surface receptors, they trigger a vast …