Selective depletion of nerve growth factor receptor‐bearing neurons in the basal forebrain
cholinergic nuclei by the immunotoxin 192 IgG‐saporin offers a new and highly useful tool …

Two experiments examined the effects of cholinergic basal forebrain lesions by
intraventricular and intrahippocampal infusions of the immunotoxin 192 IgG-saporin on …

The basal forebrain cholinergic system, which innervates widespread cortical and limbic
structures, has traditionally been considered important for learning and memory. The use of …

Use of the selective immunotoxin; 192 IgG-saporin, is helping to elucidate the role of the
cholinergic system in cognition by overcoming the problems of interpretation associated with …

Rationale. Excitotoxic lesions of the nucleus basalis magnocellularis (nbm) in rats produce
deficits in performance of the 5-choice serial reaction time (5CSRT) task, suggesting that …

The present experiment was designed to study changes in behavior following
immunolesioning of the basal forebrain cholinergic system. Rats were lesioned at 3 months …

The advent of the selective cholinergic toxin, 192 IgG-saporin, dramatically shaped
subsequent research on the role of the basal forebrain in learning and memory. In particular …

The cholinergic system has been widely implicated in cognitive processes and cholinergic
loss is a classical hallmark in Alzheimer disease. Increasing evidence supports a role of the …

Four groups of monkeys (Callithrix jacchus) were injected with saline or increasing amounts
of the immunotoxin, ME20. 4 IgG-saporin, directly into the basal nucleus of Meynert via a …

The degree of lesion produced by 192 IgG-saporin relative to controls was compared using
three independent methods. Microdialyzed acetylcholine (ACh), choline acetyltransferase …