Human choline dehydrogenase (CHD) is located in the inner membrane of mitochondria
primarily in liver and kidney and catalyzes the oxidation of choline to glycine betaine. Its …

Although choline has proven useful in the treatment of neurological disorders, its duration of
action is limited by its rapid rate of metabolism. In order to evaluate the role of choline …

Choline oxidase catalyzes the oxidation of choline to glycine betaine through a two-step,
four-electron reaction with betaine aldehyde as an intermediate. Oxygen is the final electron …

The oxidation of alcohols to aldehydes is catalyzed by a number of flavin-dependent
enzymes, which have been grouped in the glucose-methanol-choline oxidoreductase …

The oxidation of choline catalyzed by choline oxidase includes two reductive half-reactions
where FAD is reduced by the alcohol substrate and by an aldehyde intermediate transiently …

Choline dehydrogenase (CHDH) catalyzes the conversion of choline to betaine, an
important methyl donor and organic osmolyte. We have previously identified single …

Choline oxidase from Arthrobacter globiformis, which is involved in the biosynthesis of
glycine betaine from choline, has been extensively characterized in its mechanistic and …

In humans, the important water soluble, vitamin‐like nutrient choline, is taken up with the diet
or recycled in the liver. Deficiencies of choline have only been reported in experimental …

Acetyl-coenzyme A carboxylases (ACCs) have crucial roles in fatty acid metabolism in most
living organisms. Mice deficient in ACC2 have continuous fatty acid oxidation and reduced …

The FAD-dependent choline oxidase catalyzes the four-electron oxidation of choline to
glycine-betaine, with betaine-aldehyde as intermediate. The enzyme is capable of accepting …