In neural cells, such as oligodendrocytes and neurons, transport of certain RNAs along
microtubules is mediated by the cis-acting heterogeneous nuclear ribonucleoprotein A2 …

Abstract hnRNPA2 is a major component of mRNA transport granules in oligodendrocytes
and neurons. However, the structural details of how hnRNPA2 binds the A2 recognition …

Oligodendrocytes myelinate neuronal axons in the central nervous system (CNS) facilitating
rapid transmission of action potentials by saltatory conduction. Myelin basic protein (MBP) is …

In neurons, many different RNAs are targeted to dendrites where local expression of the
encoded proteins mediates synaptic plasticity during learning and memory. It is not known …

The targeting of mRNAs to specific subcellular locations is believed to facilitate the rapid and
selective incorporation of their protein products into complexes that may include membrane …

Myelination in the central nervous system provides a unique example of how cells establish
asymmetry. The myelinating cell, the oligodendrocyte, extends processes to and wraps …

Mice homozygous for the recessive mutation myelin deficient (mld) exhibit a severe deficit in
the synthesis of myelin basic protein (MBP). The primary defect in mld mice is an unusual …

We have studied transport and localization of MBP mRNA in oligodendrocytes in culture by
microinjecting labeled mRNA into living cells and analyzing the intracellular distribution of …

The polarized cell morphology of neurons dictates many neuronal processes, including the
axodendridic transport of specific mRNAs and subsequent translation. mRNAs together with …

In the central nervous system (CNS) of most vertebrates, oligodendrocytes enwrap neuronal
axons with extensions of their plasma membrane to form the myelin sheath. Several proteins …