Introduction: In the past two decades, there has been a spiraling increase in the complexity
and specificity of drug–receptor targets. It is possible to design drugs for these diverse …

High-throughput screening (HTS) methodologies for lead identification in drug discovery
were developed in the 1980s to enable the utilization of advances in genomics and …

Water solubility is a key parameter in drug formulation since it highly influences drug
pharmacokinetics and pharmacodynamics. In the past decades, the challenge with poorly …

It is estimated that 40% of active new chemical entities (NCEs) identified in combinatorial
screening programs employed by many pharmaceutical companies are poorly water …

The low water solubility of pharmacoactive molecules limits their pharmacological potential,
but the solubility parameter cannot compromise, and so different approaches are employed …

A wide variety of new medication disclosures launched by specific benefits of the general
public are laced with poor aqueous solubility problems that often obstruct their bioavailability …

Selecting the appropriate formulation and solubility-enabling technology for poorly water
soluble drugs is an essential element in the development of formulations for paediatric …

Solubility is not to be confused with the ability to dissolve or liquefy a substance, since this
process may occur not only because of dissolution but also because of a chemical reaction …

Drugs with low water solubility are predisposed to low and variable oral bioavailability and,
therefore, to variability in clinical response. Despite significant efforts to “design in” …

A drug's aqueous solubility is defined as the ability to dissolve in a particular solvent, and it
is currently a major hurdle in bringing new drug molecules to the market. According to some …