In mammals, active demethylation of sperm pronuclear DNA shortly after fertilisation is
thought to be important for reprogramming subsequent embryonic development [1–3]. A …

Epigenetic modifications serve as an extension of the information content by which the
underlying genetic code may be interpreted. These modifications mark genomic regions and …

DNA methylation is of paramount importance for mammalian embryonic development. DNA
methylation has numerous functions: it is implicated in the repression of transposons and …

The development of germ cells is a highly ordered process that begins during fetal growth
and is completed in the adult. Epigenetic modifications that occur in germ cells are important …

Alterations to DNA methylation have been attributed to in vitro culture and may affect normal
embryo development. We chose to analyze DNA methylation reprogramming in the rabbit …

The fertilized mouse egg actively demethylates the paternal genome within a few hours after
fertilization, whereas the maternal genome is only passively demethylated by a replication …

Global demethylation is part of a conserved program of epigenetic reprogramming to naive
pluripotency. The transition from primed hypermethylated embryonic stem cells (ESCs) to …

Genome-wide changes of DNA methylation by active and passive demethylation processes
are typical features during preimplantation development. Here we provide an insight that …

Embryonic stem cells (ESCs) are pluripotent, self‐renewing cells. These cells can be used in
applications such as cell therapy, drug development, disease modeling, and the study of …

Methylation patterns of specific genes have been studied by polymerase chain reaction and
found to undergo dynamic changes in the germ line and early embryo. Some CpG sites are …