Embryonic development is a complex and dynamic process with frequent changes in gene
expression, ultimately leading to cellular differentiation and commitment of various cell lines …

Genomic levels of DNA methylation undergo widespread alterations in early embryonic
development. However, changes in embryonic methylation have proven difficult to study at …

Background DNA methylation is reprogrammed during early embryogenesis by active and
passive mechanisms in advance of the first differentiation event producing the embryonic …

DNA methylation patterns are reprogrammed in primordial germ cells and in preimplantation
embryos by demethylation and subsequent de novo methylation. It has been suggested that …

One of the most critical epigenetic signatures present in the genome of higher eukaryotes is
the methylation of DNA at the C-5 position of the cytosine ring. Based on the sites of DNA …

DNA methylation is a tightly regulated epigenetic mark associated with transcriptional
repression. Next-generation sequencing of purified methylated DNA obtained from early …

DNA methylation occurs at cytosines, predominantly in the CpG dinucleotide context and is
a key epigenetic regulator of embryogenesis and stem-cell differentiation in mammals. The …

The methylation pathway, which consists of two metabolic cycles of nutrients, ie, the
methionine and folate cycles, generates S‐adenosylmethionine, the methyl donor for the …

DNA methylation is extensively reprogrammed during the early phases of mammalian
development, yet genomic targets of this process are largely unknown. We optimized …

The use of assisted reproductive technology (ART) to overcome fertility problems has
continued to increase since the birth of the first baby conceived by ART over 30 years ago …