There is increasing evidence in both plants and animals that epigenetic marks are not
always cleared between generations. Incomplete erasure at genes associated with a …

DNA methylation is extensively reprogrammed during the early phases of mammalian
development, yet genomic targets of this process are largely unknown. We optimized …

DNA methylation is essential for the control of a number of biological mechanisms in
mammals [1]. Mammalian development is accompanied by two major waves of genome …

The transgenic sequences in the mouse line TKZ751 are demethylated on a DBA/2 inbred
strain background but become highly methylated at postimplantation stages in offspring of a …

Publisher Summary This chapter discusses the deoxyribonucleic acid (DNA) methylation
from embryo to adult. The existence of tissue-specific methylation patterns and the results of …

In mammals, methylation occurs almost exclusively on the CpG dinucleotide in DNA and
shows no preference for sequence context surrounding this target. CpGs are found on many …

Dynamic epigenetic modification of the genome occurs during early development of the
mouse. Active demethylation of the paternal genome occurs in the zygote, followed by …

ABSTRACT A number of transgenes in the mouse show variation in methylation and
expression phenotypes dependent on parental transmission. It appears that there exist at …

DNA methylation is a vital epigenetic mark that participates in establishing and maintaining
chromatin structures and regulates gene transcription during mammalian development and …

Fundamental to genomic imprinting in mammals is the acquisition of epigenetic marks that
differ in male and female gametes at 'imprinting control regions'(ICRs). These marks mediate …