Publisher Summary This chapter discusses the neuroanatomy of cortical cholinergic
innervation in the human brain and its implications for behavior. The cholinergic innervation …

Publisher Summary The cholinergic innervation of the cerebral cortex has now become one
of the most dynamic areas of research and offers exciting opportunities for exploring the …

Publisher Summary The existence of a correlation between the loss of choline
acetyltransferase (ChAT) activity and the severity of the dementia in Alzheimer's disease …

Great emphasis is being placed on identification of neurotransmitter systems involved in the
symptomatic manifestations of neurological and psychiatric disorders. In the case of …

Monoclonal antibodies to choline acetyltransferase and a histochemical method for the
concurrent demonstration of acetylcholinesterase and horseradish peroxidase were used to …

Choline acetyltransferase and acetylcholinesterase enzymatic activities were measured in
33 cytoarchitectonic subregions of the cerebral cortex in two rhesus monkeys. As expected …

The present paper reviews three types of evidence implicating the role of acetylcholine in
human memory and dementia:(1) neuropathological evidence that the cholinergic …

Publisher Summary The cholinergic system of the brain has been implicated in memory
function. Evidence for this role is anatomical, physiological and pharmacological. In all …

A histochemical method for acetylcholinesterase was used to assess the regional density of
acetylcholinesterase-rich (putatively cholinergic) axons in the cerebral cortex. A dense …

Publisher Summary This chapter describes the cholinergic system in Alzheimer disease
(AD). Choline acetyltransferase (ChAT), the synthetic enzyme for acetylcholine (ACh), is …