Allograft outcome depends on a range of factors, including donor age, the allo-immune
response, ischemia–reperfusion injury, and interstitial fibrosis of the allograft. Changes in …

Background Although kidney transplantation improves patient survival and quality of life,
long-term results are hampered by both immune-and non-immune-mediated complications …

The burden of chronic kidney disease is dramatically rising, making it a major public health
concern worldwide. Kidney transplantation is now the best treatment for patients with end …

Background Ischemia during kidney transplant causes chronic allograft injury and adversely
affects outcome, but the underlying mechanisms are incompletely understood. In tumors …

During ageing, kidney function decreases due to renal tubular atrophy, interstitial fibrosis,
glomerulosclerosis and arteriosclerosis. Recently, changes in DNA methylation were shown …

Chronic kidney disease (CKD) is an emerging public health priority associated with high
mortality rates and demanding treatment regimens, including life-style changes, medications …

Identification of patients at risk for post-transplant complications is a major challenge, but it
will improve clinical care and patient health after organ transplantation. The poor predictive …

Introduction Kidney transplantation remains the gold standard of treatment for end-stage
renal disease (ESRD), with improved patient outcomes compared with dialysis. Epigenome …

Background. In clinical transplantation, ischemia-reperfusion injury (I/RI) causes damage to
DNA. We hypothesize that one form of damage is the demethylation of methylated cytosines …

Renal disease is the common denominator of a number of underlying disease conditions,
whose prevalence has been dramatically increasing over the last two decades. Two aspects …