Biomarkers of dementia with Lewy bodies: differential diagnostic with Alzheimer's disease

O Bousiges, F Blanc - International Journal of Molecular Sciences, 2022 - mdpi.com
Dementia with Lewy Bodies (DLB) is a common form of cognitive neurodegenerative
disease. Only one third of patients are correctly diagnosed due to the clinical similarity …

Diagnostic value of cerebro-spinal fluid biomarkers in dementia with lewy bodies

O Bousiges, F Blanc - Clinica Chimica Acta, 2019 - Elsevier
Abstract Dementia with Lewy Bodies (DLB) is the second most common form of dementia
after Alzheimer's disease (AD), accounting for 15% to 20% of neuropathologically defined …

The diagnostic value of CSF α-synuclein in the differential diagnosis of dementia with Lewy bodies vs. normal subjects and patients with Alzheimer's disease

E Kapaki, GP Paraskevas, E Emmanouilidou… - PloS one, 2013 - journals.plos.org
The detection of α-synuclein (α-syn) in the cerebrospinal fluid (CSF) of patients with
synucleinopathy has yielded promising but inconclusive results. The aim of the present …

Biomarkers in dementia with Lewy bodies: a review

N Sinha, M Firbank, JT O'Brien - International journal of geriatric …, 2012 - Wiley Online Library
Background Dementia with Lewy bodies (DLB) shares common clinical, neuropsychological
and pathological features with other dementia subtypes, such as Alzheimer's disease (AD) …

Cerebrospinal fluid, imaging, and physiological biomarkers in dementia with Lewy bodies

I Mavroudis, F Petridis, D Kazis - American Journal of …, 2019 - journals.sagepub.com
Dementia with Lewy bodies is a progressive neurodegenerative disorder, clinically
characterized by gradual cognitive impairment and fluctuating cognition, behavioral …

Early discriminatory diagnosis of dementia with Lewy bodies: The emerging role of CSF and imaging biomarkers

D Aarsland, M Kurz, M Beyer, K Bronnick… - Dementia and geriatric …, 2008 - karger.com
Background: The clinical diagnostic criteria for dementia with Lewy bodies (DLB) have a low
sensitivity, and there are no generally accepted biomarkers to distinguish DLB from other …

Using cerebrospinal fluid marker profiles in clinical diagnosis of dementia with Lewy bodies, Parkinson's disease, and Alzheimer's disease

L Kaerst, A Kuhlmann, D Wedekind… - Journal of …, 2014 - content.iospress.com
Background: Dementia with Lewy bodies (DLB) is difficult to differentiate from other neuro-
degenerative diseases. Patients are often mistaken to suffer from Parkinson's disease (PD) …

Differential diagnostic value of total alpha-synuclein assay in the cerebrospinal fluid between Alzheimer's disease and dementia with Lewy bodies from the prodromal …

O Bousiges, N Philippi, T Lavaux… - Alzheimer's Research & …, 2020 - Springer
Background Several studies have investigated the value of alpha-synuclein assay in the
cerebrospinal fluid (CSF) of Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) …

α-synuclein antibodies recognize a protein present at lower levels in the CSF of patients with dementia with Lewy bodies

C Ballard, EL Jones, E Londos, L Minthon… - International …, 2010 - cambridge.org
Background: Dementia with Lewy bodies (DLB) accounts for 15–20% of the millions of
people worldwide with dementia. Accurate diagnosis is essential to avoid harm and optimize …

Decreased α-synuclein serum levels in patients with Lewy body dementia compared to Alzheimer's disease patients and control subjects

C Laske, AJ Fallgatter, E Stransky, K Hagen… - Dementia and geriatric …, 2011 - karger.com
Background/Aims: Detection and differentiation of neurodegenerative dementias, such as
dementia with Lewy bodies (DLB) and Alzheimer's disease (AD), with blood-based …