Co-inhibitory receptors, such as CTLA-4 and PD-1, have an important role in regulating T
cell responses and have proven to be effective targets in the setting of chronic diseases …

Co-inhibitory receptors play a key role in regulating T cell responses and maintaining
immune homeostasis. Their inhibitory function prevents autoimmune responses but also …

Immune regulation is critical for the maintenance of peripheral self-tolerance and for down-
regulation of immune responses. Understanding its mechanisms may permit the …

Highlights•Inhibitory receptors (IRs) play an important role in limiting autoimmunity.•IR
genetic deletion or antibody blockade exacerbates autoimmunity in mouse models.•SNPs …

Inhibitory receptors mediate CD8 T-cell hyporesponsiveness against cancer and infectious
diseases. PD-1 and CTLA-4 have been extensively studied, and blocking antibodies have …

Co-inhibitory receptors are important regulators of T-cell function that define the balance
between tolerance and autoimmunity. The immune regulatory function of co-inhibitory …

T cell activation is tightly regulated by both stimulatory and inhibitory co-receptors and has
been a focus in the development of interventions for managing cancer or autoimmune …

Although immunotherapeutics targeting the inhibitory receptors (IRs) CTLA-4, PD-1 or PD-
L1 have made substantial clinical progress in cancer, a considerable proportion of patients …

Summary LAG-3, TIM-3, and TIGIT comprise the next generation of immune checkpoint
receptors being harnessed in the clinic. Although initially studied for their roles in restraining …

The success of tumor immunotherapy targeting the inhibitory co-receptors PD-1 and CTLA-4
has indicated that many other co-receptors might be potential druggable targets, despite …